EDJ

GROWTH FACTOR RECEPTOR BOUNDED PROTEIN 2 AND HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR 2 EXPRESSION IN KERATOCYSTIC ODONTOGENIC TUMOR

Sarah M.S., Amr H. El-Bolok And Enas A.A.,

ABSTRACT
Aim Of Study: To Evaluate The Expression Of Growth Factor Receptor Bounded Protein 2 (Grb2) And Human Epidermal Growth Factor Receptor2 (HER2) In Keratocystic Odontogenic Tumor (KCOT).

Materials and Methods: 30 KCOT Paraffin Blocks Were Stained Immunohistochemically For Grb2 And HER2. Immunostaining Was Measured As Area Fraction And The Results Were Analyzed Statistically. P Value < 0.05 Was Considered Significant.

Results: All Cases Of KCOT Showed Positive Nuclear And Cytoplasmic Reaction For Grb2 And Nuclear Reaction For HER2. A Significant Positive Correlation Was Found Between HER2 And Grb2 Expression In KCOT. Conclusion: HER2 And GRB2 Play A Significant Role In The Proliferation, Pathogenesis And Progression Of KCOT. Grb2/HER2 Signaling Pathway Plays A Role In The Pathogenesis Of KCOT.

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